Deworming helminth co-infected individuals for delaying HIV disease progression.

摘要: BACKGROUND The HIV-1 pandemic has disproportionately affected individuals in resource-constrained settings where other infectious diseases, such as helminth infections, also are highly prevalent. There biologically plausible reasons for possible effects of infection HIV-1-infected individuals, and findings from multiple studies suggest that may adversely affect progression. Since initial publication this review (Walson 2007), additional data randomized controlled trials (RCTs) become available. We sought to evaluate all currently available evidence determine if treatment co-infected impacts OBJECTIVES To treating with can reduce the progression determined by changes CD4 count, viral load, or clinical disease SEARCH STRATEGY In 2008 update, we searched online published unpublished Cochrane Library, MEDLINE, EMBASE, CENTRAL, AIDSEARCH. databases listing conference abstracts, scanned reference lists articles, contacted authors included studies. SELECTION CRITERIA RCTs quasi-RCTs compared measured infected receiving anti-helminthic therapy. DATA COLLECTION AND ANALYSIS Data regarding RNA levels, and/or staging after co-infection were extracted identified MAIN RESULTS Of 7,019 abstracts (6,384 original searches plus 635 updated searches), 17 meeting criteria potential inclusion (15 previous an two RCTs). After restricting RCTs, a total three eligible review.All showed individual beneficial eradication on markers (HIV-1 counts). When these pooled, analysis demonstrated significant benefit deworming both plasma counts. AUTHORS' CONCLUSIONS date, have evaluated individuals. All demonstrate attenuating reducing load increasing taken together, there is adults. Given different species interventions, further warranted species-specific document long-term outcomes following deworming.