Immune System Modulation by Helminth Infections: Potential Impact on HIV Transmission and Disease Progression

摘要: The co-prevalence of helminth and HIV-1 infections in sub-Saharan Africa has fueled the suspicion that constitute an important factor contributing to high HIV prevalence this region. Furthermore, it been hypothesized anti-helminthic treatment co-infected HIV-positive patients is a potentially cost effective public health measurement delays disease progression thus eligibility antiretroviral therapy. Here we review scientific data on interaction between different species epidemiological level address pathogenic mechanisms have increase susceptibility or rate helminth-HIV patients. We first focus basic concepts transmission, pathogenesis then aim consolidate available from human cohort studies, animal models vitro experiments provide coherent overview current state knowledge field.