Kidney disease as a risk factor for recurrent cardiovascular disease and mortality

摘要: Abstract Background: Chronic kidney disease (CKD) is highly prevalent in the United States and an independent risk factor for adverse cardiovascular (CVD) all-cause mortality outcomes patients with acute coronary syndromes. Few studies have evaluated effect of CKD on events a diverse community-based population underlying CVD. Methods: Data subjects preexisting CVD were pooled from 4 publicly available, community-based, longitudinal studies: Atherosclerosis Risk Communities, Cardiovascular Health Study, Framingham Heart Offspring Study. was defined as estimated glomerular filtration rate less than 60 mL/min/1.73 m 2 ( ). The primary study outcome composite myocardial infarction (MI), fatal heart (CHD), stroke, mortality. secondary included only MI CHD. Results: A total 4,278 satisfied inclusion criteria, 759 (17.7%) had CKD. Mean follow-up 86 months. observed 1,703 (39.8%) 857 (20.0%), respectively. Incidence rates greater persons compared those without (62.5% versus 34.9% 30.6% 17.8%, respectively). Adjusted hazard ratios 1.35 (95% confidence interval [CI], 1.21 to 1.52) 1.32 CI, 1.12 1.55), Conclusion: presence associated increased recurrent outcomes. This persists after adjustment traditional factors.