Incidence of and risk factors for neurologic complications after heart transplantation.

摘要: Abstract Introduction Following heart transplantation (HT), neurologic complications occur in 50% to 70% of patients, mostly the perioperative period. The objective our study was analyze frequency and impact factors related development neurological after HT. Materials methods HT patients with survival greater than 1 month (November 1987 May 2003) were included. Heart–lung transplants, retransplants, pediatric excluded. Neurologic defined as a event requiring hospitalization or detected hospital. Groups included ischemic hemorrhagic stroke, seizures, neurotoxicity other (e.g., infections, headaches, Alzheimer’s). Results We assessed 322 (87.6% men, 12.4% women) grouped them according presence during follow-up. There no differences baseline characteristics between two groups. Of studied, 13.7% suffered complication: stroke (3.5%), (2.9%), seizures (1.9%), (1.6%). Only cases (0.6%) observed. Associations pretransplant risk diabetes mellitus (OR, 6.54; 95% CI, 1.28 33.6, P = .024), renal failure 5.95; 1.03 34.3; .046), prior valvular disease 4.96, 1.22 20.1; .045). number infections 1.35, 1.05 1.73; .02). No found complications. Conclusions incidence series 13.7%. most frequent complication stroke. Valvular underlying associated Diabetes seizures. posttransplant