Pharmacomechanical Coupling: The Membranes Talk to the Crossbridges

摘要: Excitation-contraction (E-C) coupling in smooth muscle (Table 1) is distinguished by the importance of pharmacomechanical coupling: a complex signal transduction mechanisms that not directly dependent on changes membrane potential (Somlyo and Somlyo, 1968). In contrast, striated electromechanical dominant E-C mechanism. We shall emphasize this overview, only because its our interest it, but also there has been major progress understanding molecular mechanisms, particularly Ca2+ release modulation Ca2+-sensitivity.