A review of the pattern of AIDS defining, HIV associated neoplasms and premalignant lesions diagnosed from 2000-2011 at Kenyatta National Hospital, Kenya.

摘要: Sub-Sahara Africa hosts up to 71 % of all HIV infected people in the world. With this high incidence Human immunodeficiency virus ( HIV) comes burden co-morbidities such as malignant and premalignant lesions. Aids defining malignancies have been listed Kaposi’s sarcoma, Non-Hodgkin’s lymphoma invasive squamous cell carcinoma cervix. People with HIV/AIDS(PLWAS) a higher risk developing these neoplasms than rest population. The pathogenesis has linked immune suppression, persistent antigenic stimulation cytokine dysregulation. Current study analyzes presents patterns trends presentation related patients diagnosed through histopathology at Kenyatta National Hospital. To describe AIDS- non-AIDS- lesions 10 years pre- post HAART period hospital, Kenya. This was hospital based descriptive cross sectional study. Formalin fixed paraffin embedded (FFPE) blocks histological reports between 2000 2011 were traced from archives. patients’ demographic data clinical entered an excel spreadsheet diagnosis coding confirmed by histopathologist. then cleaned analyzed using SSPS version 17.0 Ink. A total 173 reviewed analyzed. Of 118 (68 %) females 55 males (32 %). male female ratio 1:2. age range two 56 years median 36 years. Kaposi sarcoma is leading AIDS malignancy Kenya while conjunctiva non-AIDS malignancy. closely followed cervix NHL. associated neoplasm Physicians caretakers managing following on HIV/AIDS should look out for form IRIS institution patients. increasing PLWAS There therefore need introduce early screening programs intraepithelial