The course of Kaposi's sarcoma, a marker disease for the initial diagnosis of AIDS, under ongoing cART.

摘要: While Kaposi's sarcoma (KS) was common in the 1980s and early 1990s HIV-positive patients one of most AIDS-defining diseases, its prevalence today has decreased significantly due to widespread use chimeric antigen receptor T-cell (cART) therapy. The rapid initiation cART or, if occurring during ongoing cART, an optimization antiretroviral therapy leads a healing this tumour disease patients. aim is immune reconstitution, as immunodeficiency resulting from HIV (reduced CD4+-T helper cells) promotes development spread KS. This case report describes course KS first diagnosis AIDS 36-year-old patient. copy count below detection limit CD3+/CD4+ T-helper cell only slightly normal value six-month follow-up after initial However, clinical findings one-year showed partial response, whereby it noted that new lesions also developed focally addition individual progressive lesions. demonstrated clinically, dermatoscopically by laser Doppler fluxmetry measurements Such progression observed about one-third affected various studies called Immune Reconstitution Inflammatory Syndrome. Other therapies are necessary here suppress immunological phenomenon (including cytostatic drugs). Promising currently underway, including utilising checkpoint inhibitors. These great therapeutic interest high activity itself usually systemic inflammatory response syndrome.