Huperzine A derivatives, their preparation and their use
作者： Takuji Yamaguchi , Cheng Zhu , Jinlai Lin , Guansong Wu , Jingkang Shen
DOI:
关键词:
摘要: The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is (a), or R' and together form =CH; R (C1-C5)alkyl, (b), (c), (d), n 0 1, X H, (C1-C5)alkyl; (C1-C5)alkyloxy; nitro, halogen, carboxy, alkyloxycarbonyl, hydroxymethyl, hydroxy, amino substituted by bis -(C1-C5)alkyl; -(CH2mCOOZ, m=0∩5, Z H -CH=CH-G, G phenyl, furanyl, alkyloxycarbonyl; dihydro- tetrahydro-pyridyl1 (C1-C5)alkyl at the nitrogen atom; pyridoyl, benzoyl processes for their manufacture use as acetyl cholinesterase inhibitor.
google.com.ar 参考文章(9)
Xi-can Tang, Yan-yi Han, Chao-mei Yu, Jia-sen Liu, Huperzines and analogs ,(1990)
Jose Alexander, Acyloxyisopropyl carbamates as prodrugs for amine drugs ,(1994)
Jia-Sen Liu, Yuan-Long Zhu, Chao-Mei Yu, You-Zuo Zhou, Yan-Yi Han, Feng-Wu Wu, Bao-Feng Qi, The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity Canadian Journal of Chemistry. ,vol. 64, pp. 837- 839 ,(1986) , 10.1139/V86-137
Alan P. Kozikowski, Yan Xia, E. Rajarathnam Reddy, Werner Tuckmantel, Israel Hanin, X. C. Tang, Synthesis of Huperzine A and Its Analogues and Their Anticholinesterase Activity Journal of Organic Chemistry. ,vol. 56, pp. 4636- 4645 ,(1991) , 10.1021/JO00015A014
A. P. KOZIKOWSKI, Y. XIA, E. R. REDDY, W. TUECKMANTEL, I. HANIN, X. C. TANG, Synthesis of Huperzine A (I) and Its Analogues and Their Anticholinesterase Activity. ChemInform. ,vol. 22, ,(1991) , 10.1002/CHIN.199152303
Alan P. Kozikowski, Huperzine a analogs as acetylcholinesterase inhibitors ,(1991)
Kenneth L. Kirk, John W. Daly, Kenneth A. Jacobson, Adenosine receptor prodrugs ,(1987)
Alan Paul Kozikowski, Yan Xia, Method for the synthesis of huperzine a and analogs thereof and compounds useful therein Official Gazette of the United States Patent and Trademark Office Patents. ,vol. 1202, pp. 495- 496 ,(1990)
Ruyun J, Studies on molecular modification of novel constituents of chinese medicinal plants. Medicinal Chemistry Research. ,vol. 5, pp. 587- 594 ,(1995)