Huperzine A Processes and Related Compositions and Methods of Treatment

作者: Seth Herzon , Maung Kway Moe Tun

DOI:

关键词:

摘要: The invention provides (1) processes for making substantially-pure (-) huperzine A and derivatives; (2) compositions useful in (3) methods of treating or preventing neurological disorders using derivatives.

参考文章(62)
Takuji Yamaguchi, Cheng Zhu, Jinlai Lin, Guansong Wu, Jingkang Shen, Shanhao Jiang, Dayuan Zhu, Takeshi Wakamatsu, Xican Tang, Kazuhiro Tanaka, Hiroaki Nishimura, Huperzine A derivatives, their preparation and their use ,(1995)
Steven C. Schachter, Use of huperzine for disorders ,(2006)
Alan P. Kozikowski, E. Rajarathnam Reddy, Chris P. Miller, A simplified route to a key intermediate in the synthesis of the Chinese nootropic agent huperzine A Journal of The Chemical Society-perkin Transactions 1. pp. 195- 197 ,(1990) , 10.1039/P19900000195
Edward M. Burgess, Harold R. Penton, E. A. Taylor, Thermal reactions of alkyl N-carbomethoxysulfamate esters Journal of Organic Chemistry. ,vol. 38, pp. 26- 31 ,(1973) , 10.1021/JO00941A006
Hai Yan Zhang, Xi Can Tang, Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease Trends in Pharmacological Sciences. ,vol. 27, pp. 619- 625 ,(2006) , 10.1016/J.TIPS.2006.10.004
Yan Xia, Alan P. Kozikowski, A practical synthesis of the Chinese "nootropic" agent huperzine A: a possible lead in the treatment of Alzheimer's disease Journal of the American Chemical Society. ,vol. 111, pp. 4116- 4117 ,(1989) , 10.1021/JA00193A062
Phillip RADLICK, Lauren R. BROWN, A Versatile Modification of the Hofmann Rearrangement Synthesis. ,vol. 1974, pp. 290- 292 ,(1974) , 10.1055/S-1974-23298