Endobronchial ultrasound-guided transbronchial needle aspiration for staging of lung cancer: A systematic review and meta-analysis

摘要: Study objectives Recently, less invasive methods have emerged as potential alternatives for staging with tissue confirmation of suspected metastatic mediastinal lymph nodes in lung cancer. The objective this review was to assess the overall diagnostic accuracy EBUS-TBNA detecting node cancer a meta-analysis. Methods The MEDLINE, EMBASE, Cancerlit and Cochrane Library database, from January 1995 September 2008, were searched studies evaluating accuracy. Meta-analysis used pool sensitivity specificity construct summary receiver-operating characteristic. Results A total 11 1299 patients, who fulfilled all inclusion criteria, considered analysis. No publication bias found. had pooled 0.93 (95% CI, 0.91–0.94) 1.00 0.99–1.00). subgroup patients selected on basis CT or PET positive results higher (0.94, 95% CI 0.93–0.96) than without any selection (0.76, 0.65–0.85) (p < 0.05). not correlated prevalence metastasis. Only two complications occurred (0.15%). Conclusion EBUS-TBNA an accurate, safe cost-effective tool staging. metastasis may improve EBUS-TBNA. High-quality prospective regarding are still needed be conducted.