Intracranial infectious aneurysm: Presentation, management and outcome

摘要: Abstract Background Intracranial infectious aneurysms (IA) are infrequent, but can be fatal. Objectives To compare the clinical profile of IAs associated with intravascular/systemic infection like infective endocarditis that local infections meningitis, orbital cellulitis and cavernous sinus thrombosis. Methods We analysed all cases IA, treated in this Institute from 1976 to 2003, order identify prognostic factors. Results There were 25 persons (mean age 24.8±17.3 years, males 17) 29 IA (carotid circulation 19, vertebrobasilar 10). Headache (83%) fever (67%) most common presenting symptoms. In contrast noninfectious aneurysms, intracerebral haemorrhage (60%) focal signs more than subarachnoid (7%) IA. Sources cardiac (10), meningitis (12), (2) or uncertain (1). Infective agents included bacteria (18), fungi (4), tubercle bacilli (3). Fifteen distal 14 proximal. proximal (75%) while those diseases preferentially involved carotid territory ( p =0.013). The overall mortality was 32%. Survivors younger who expired =0.015). Of sixteen patients medically, seven recovered (44%), others (56%) had treatment failure (three died six required surgery later). Another five underwent early (one died). Mortality significantly higher fungal aetiology location. Conclusions different as compared endocarditis.