Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase
作者： Amos B. Smith , Setsuya Sasho , Bari A. Barwis , Paul Sprengeler , Joseph Barbosa
DOI: 10.1016/S0960-894X(98)00575-7
关键词:
摘要: A tetrahydropyran-based inhibitor (2) of mammalian ribonucleotide reductase (mRR) has been designed and synthesized based on the heptapeptide, N-AcFTLDADF (1), corresponding to C-terminus R2 subunit mRR. Inhibition studies revealed that 2 is indeed a competent inhibitor, albeit less potent than 1.
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