Investigation of 1-bromo-3-buten-2-one as building block in organic synthesis
作者： Andreas Westerlund , Jean-Louis Gras , Rolf Carlson
DOI: 10.1016/S0040-4020(01)00526-9
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摘要: Abstract 1-Bromo-3-buten-2-one is investigated as a building block for organic synthesis. Reduction to the corresponding alcohol works best with lithium aluminium hydride, reaction primary amines gives 5-membered-aza-heterocycles in moderate yields and activated methylene compounds form 5-membered-carbocycles gave unsatisfactory when one-pot-procedure was used. The first step of stepwise protocol, Michael addition, discussed.
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