Coagulation factor deficiencies during initiation of extracorporeal membrane oxygenation

摘要: Abstract Objective: We examined the hypothesis that critically ill patients receiving extracorporeal membrane oxygenation (ECMO) have reduced clotting factor levels, which may contribute to risk of hemorrhagic complications. Methods: Blood samples were collected from 19 before and 1 hour after initiation ECMO. Heparin present in was removed by ECTEOLA (epichlorohydrin triethanolamine) cellulose resin adsorption, coagulation factors assayed automated techniques. Factor deficiency defined as levels at least 2 SD less than published age-adjusted reference values. Results: Thirteen (68%) had deficiencies two or more Despite inclusion factor-containing blood products ECMO priming solution, 10 (53%) Four intracranial hemorrhages found be deficient five time cannulation. Conclusions: Severe are often requiring ECMO, provided through circuit prime insufficient ensure correction these deficiencies. Deficiency multiple hemorrhage during ECMO; practice excluding solutions should prospectively. (J PEDIATR 1995;126:900-4)