Fully Automated Continuous Flow Synthesis of Highly Functionalized Imidazo[1,2-a] Heterocycles

作者: Ananda Herath , Russell Dahl , Nicholas D. P. Cosford

DOI: 10.1021/OL902433A

关键词:

摘要: … 2-a]pyridine-2-carboxylic acids from 2-aminopyridines and bromopyruvic acid using a single … -a]pyridine-2-carboxylic acids and amides directly from 2-aminopyridines and bromopyruvic …

参考文章(59)
Donna M. Huryn, Nicholas D.P. Cosford, Chapter 26 The Molecular Libraries Screening Center Network (MLSCN): Identifying Chemical Probes of Biological Systems Annual Reports in Medicinal Chemistry Volume 42. ,vol. 42, pp. 401- 416 ,(2007) , 10.1016/S0065-7743(07)42026-7
Ian R. Ager, Alan C. Barnes, Geoffrey W. Danswan, Peter W. Hairsine, David P. Kay, Peter D. Kennewell, Saroop S. Matharu, Peter Miller, Peter Robson, Synthesis and oral antiallergic activity of carboxylic acids derived from imidazo[2,1-c][1,4]benzoxazines, imidazo[1,2-a]quinolines, imidazo[1,2-a]quinoxalines, imidazo[1,2-a]quinoxalinones, pyrrolo[1,2-a]quinoxalinones, pyrrolo[2,3-a]quinoxalinones, and imidazo[2,1-b]benzothiazoles. Journal of Medicinal Chemistry. ,vol. 31, pp. 1098- 1115 ,(1988) , 10.1021/JM00401A009
Andreas Kirschning, Wladimir Solodenko, Klaas Mennecke, Combining enabling techniques in organic synthesis: continuous flow processes with heterogenized catalysts. Chemistry: A European Journal. ,vol. 12, pp. 5972- 5990 ,(2006) , 10.1002/CHEM.200600236
Csaba Csajági, Bernadett Borcsek, Krisztián Niesz, Ildikó Kovács, Zsolt Székelyhidi, Zoltán Bajkó, László Ürge, Ferenc Darvas, High-efficiency aminocarbonylation by introducing CO to a pressurized continuous flow reactor. Organic Letters. ,vol. 10, pp. 1589- 1592 ,(2008) , 10.1021/OL7030894
Silvia Selleri, Fabrizio Bruni, Camilla Costagli, Annarella Costanzo, Gabriella Guerrini, Giovanna Ciciani, Paola Gratteri, François Besnard, Barbara Costa, Marina Montali, Claudia Martini, Jonna Fohlin, Gaetano De Siena, Petra Malmberg Aiello, A novel selective GABA(A) alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents. Journal of Medicinal Chemistry. ,vol. 48, pp. 6756- 6760 ,(2005) , 10.1021/JM058002N
Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Christoper D. Smith, Geoffrey K. Tranmer, Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles Organic Letters. ,vol. 8, pp. 5231- 5234 ,(2006) , 10.1021/OL061975C
Zhan Deng, Claudio Chuaqui, Juswinder Singh, Knowledge-based design of target-focused libraries using protein-ligand interaction constraints. Journal of Medicinal Chemistry. ,vol. 49, pp. 490- 500 ,(2006) , 10.1021/JM050381X
Namal C. Warshakoon, Shengde Wu, Angelique Boyer, Richard Kawamoto, Justin Sheville, Sean Renock, Kevin Xu, Matthew Pokross, Artem G. Evdokimov, Richard Walter, Marlene Mekel, A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors Bioorganic & Medicinal Chemistry Letters. ,vol. 16, pp. 5598- 5601 ,(2006) , 10.1016/J.BMCL.2006.08.089
Filomena Mattner, Karine Mardon, Christian Loc'h, Andrew Katsifis, Pharmacological evaluation of an [123I] labelled imidazopyridine-3-acetamide for the study of benzodiazepine receptors Life Sciences. ,vol. 79, pp. 287- 294 ,(2006) , 10.1016/J.LFS.2006.01.006