The role of B7 costimulation in benzene immunotoxicity and its potential association with cancer risk.

摘要: Benzene is a recognized human carcinogen; however, there are still some gaps in the knowledge regarding mechanism of toxicity this organic solvent and potential early biomarkers for damage caused by it. In previous study, our research group demonstrated that adhesion molecules immune system (B7.1 B7.2) could be detection immunotoxicity benzene exposure. Therefore, study was developed to deepen understanding important topic, aiming contribute comprehension mediated B7.1 B7.2 its association with risk carcinogenicity. protein expression blood monocytes gene PBMCs were evaluated. Additionally, complement C3 C4 levels serum measured, as well p53 PBMCs. Seventy-four gas station workers (GSW group) 71 non-occupationally exposed subjects (NEG) Our results decreased GSW compared NEG (n = 71) (p < 0.01). Along same lines, observed 0.01), demonstrating impairment pathway well. reduction GSA These alterations associated both exposure biomarker evaluated, urinary trans, trans-muconic acid, time 0.05). Moreover, strong correlations between vs. (r 0.830; p 0.001), 0.685; 0.702; 0.001). Taken together, these demonstrate co-stimulatory molecule affected Also, decrease expression, even at low levels, reinforces carcinogenicity effect pathway. suggest promotion evasion together may play an role mechanism. However, further targeted studies needed confirm proposition.