Benzene-associated immunosuppression and chronic inflammation in humans: a systematic review.

摘要: Objective Recent evidence has accumulated that the immune system is intimately intertwined with cancer development. Two key characteristics of carcinogens in which plays a central role are chronic inflammation and immunosuppression. In this systematic review, we investigated association inflammatory immunosuppressive outcomes benzene, widely used industrial chemical. Benzene been confirmed to cause acute myeloid leukaemia suspected non-Hodgkin lymphoma, two cancers blood-forming affect cells. Methods We systematically searched PubMed Embase for all relevant studies using combination Medical Subject Headings (MeSH) selected words. The detailed review protocol, including search strategy, was registered PROSPERO, international prospective register reviews (#CRD42019138611). Results Based on human final report new benzene-induced effect adaptive activation innate inflammation. particular, benzene significantly lowers number white blood cells, particularly lymphocytes such as CD4+ T-cells, B-cells natural killer increases proinflammatory biomarkers at low levels exposure. Conclusion To best our knowledge, first comprehensive benzene’s immunotoxicity humans. results obtained from propose potential immunotoxic mechanisms how induces leukaemia/lymphoma: (1) invasion caused by cytokine production, (2) promotion via impaired immunosurveillance. Further will be required confirm connection between exposure its effects system.