The Metaplasia-Dysplasia-Carcinoma Sequence of Barrett’s Esophagus

摘要: Characterization of the clinical and molecular pathology metaplasia-dysplasia-carcinoma sequence Barrett’s esophagus (columnar-lined esophagus, CLO) has only recently begun to resolve complexities disease first described debated nearly 50 years ago1. As with many histopathological features disease, CLO does not readily or necessarily comply known events that occur in other common epithelial neoplasms. Yet failure unravel pathogenesis neoplastic is potentially devastating: dramatic increase incidence esophageal adenocarcinoma Western communities continues at an almost epidemic manner, greater than any malignancy2,3. Advances understanding pathological mechanisms involved metaplasia-dysplasia-adenocarcinoma will surely result development markers early stages carcinogenesis this, combination surveillance, potential allow identification patients high risk change. This turn earlier intervention, either by therapy, perhaps more likely near future, application ablative surgical methods treatment. In this chapter, be discussed, concentrating on advances made our changes underpin sequence. The following chapter (3.3) also reviews genetic alterations, but mainly focussed carcinoma rather metaplasia dysplasia.