Immunohistochemical localization of metallothionein in endometrial lesions.
作者： Elli E. Ioachim , Evangelia Kitsiou , Catherin Carassavoglou , Stella Stefanaki , N. J. Agnantis
DOI: 10.1002/1096-9896(2000)9999:9999<::AID-PATH616>3.0.CO;2-Q
关键词:
摘要: Metallothioneins (MTs) are a group of ubiquitous low-molecular-weight proteins essential for the protection cells against heavy metal ion toxicity. The immunohistochemical expression MT was studied by immunohistochemistry using monoclonal antibody (E9) conserved epitope I and II isoforms in series 89 endometrial carcinomas, 34 cases hyperplasia, 32 samples normal endometrium. In secretory phase endometrium, extensive detected most (92.4%). contrast, immunoreactivity confined to small foci 22.2% proliferative cases. values endometrium were inversely correlated with oestrogen receptor (ER) content (p<0.0001), progesterone (PgR) PCNA (p<0.0001) MIB1 (p=0.001) scores. hyperplastic lesions, only 3.3% cases, while carcinomas it observed 23.1%. A statistically significant difference between simple hyperplasias (p=0.03). positively grade (p=0.0065), (p=0.022), p53 (p=0.006) expression, PgR trend inverse correlation ER also (p=0.07). These data suggest that seems be under hormonal control endometrium; may modify expression; could used as an additional biological marker indicating aggressive behaviour lesions.
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