Clonal overexpression of metallothionein is induced by somatic mutation in morphologically normal colonic mucosa.

作者: Bharat Jasani , Fiona Campbell , Hossein Navabi , Kurt W. Schmid , Geraint T. Williams

DOI: 10.1002/(SICI)1096-9896(199802)184:2<144::AID-PATH998>3.0.CO;2-J

关键词: Molecular biologyRatónMutationGene expressionImmunostainingCell growthCryptCarcinogenesisPathologyBiologyGermline mutation

摘要: Metallothionein (MT) overexpression occurs frequently in human tumours but the underlying mechanism is unknown. Morphologically normal‐appearing mucosa from human colorectal …

参考文章(22)
D. Williams, A. P. Lowes, E. D. Williams, G. T. Williams, A stem cell niche theory of intestinal crypt maintenance based on a study of somatic mutation in colonic mucosa. American Journal of Pathology. ,vol. 141, pp. 773- 776 ,(1992)
Jeremias H.R. Kägi, Overview of metallothionein. Methods in Enzymology. ,vol. 205, pp. 613- 626 ,(1991) , 10.1016/0076-6879(91)05145-L
YOSHIHIRO NOZAWA, NICO VAN BELZEN, ANGELIQUE C. J. VAN DER MADE, WINAND N. M. DINJENS, FRED T. BOSMAN, Expression of nucleophosmin/B23 in normal and neoplastic colorectal mucosa The Journal of Pathology. ,vol. 178, pp. 48- 52 ,(1996) , 10.1002/(SICI)1096-9896(199601)178:1<48::AID-PATH432>3.0.CO;2-Y
D. �fner, W. B�cker, K.W. Schmid, B. Riedmann, T. Bammer, A. Rumer, H. Maier, G. Winde, B. Jasani, Immunohistochemical metallothionein expression in colorectal adenocarcinoma: correlation with tumour stage and patient survival Virchows Archiv. ,vol. 425, pp. 491- 497 ,(1994) , 10.1007/BF00197552
B. A. Masters, E. J. Kelly, C. J. Quaife, R. L. Brinster, R. D. Palmiter, Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 584- 588 ,(1994) , 10.1073/PNAS.91.2.584
Fiona A. Stennard, Adele F. Holloway, Jenny Hamilton, Adrian K. West, Characterisation of six additional human metallothionein genes Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. ,vol. 1218, pp. 357- 365 ,(1994) , 10.1016/0167-4781(94)90189-9
J. J. van den Oord, M. De Ley, Distribution of metallothionein in normal and pathological human skin Archives of Dermatological Research. ,vol. 286, pp. 62- 68 ,(1994) , 10.1007/BF00375845
ANGELO P. DEI TOS, CLAUDIO DOGLIONI, SARA PICCININ, ROBERTA MAESTRO, THOMAS MENTZEL, MATTIA BARBARESCHI, MAURO BOIOCCHI, CHRISTOPHER D. M. FLETCHER, Molecular abnormalities of the p53 pathway in dedifferentiated liposarcoma. The Journal of Pathology. ,vol. 181, pp. 8- 13 ,(1997) , 10.1002/(SICI)1096-9896(199701)181:1<8::AID-PATH700>3.0.CO;2-#
K. W. Schmid, I. O. Ellis, Julia M. W. Gee, Barbara M. Darke, Wendy E. Lees, J. Kay, A. Cryer, J. M. Stark, A. Hittmair, D. Öfner, Martina Dünser, R. Margreiter, G. Daxenbichler, R. I. Nicholson, B. Bier, W. Böcker, B. Jasani, Presence and possible significance of immunocytochemically demonstrable metallothionein over-expression in primary invasive ductal carcinoma of the breast. Virchows Archiv. ,vol. 422, pp. 153- 159 ,(1993) , 10.1007/BF01607167
Jin Zeng, Rainer Heuchel, Walter Schaffner, Jeremias H.R. Kägi, Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Spl FEBS Letters. ,vol. 279, pp. 310- 312 ,(1991) , 10.1016/0014-5793(91)80175-3