Studies on the stereochemistry of addition reactions on cyclohexanones VII: The effect of the axial ester group on the reactivity of trans 2-decalones
作者： Giorgio Di Maio , Weimin Li , Luisa Migneco , Elisabetta Vecchi
DOI: 10.1016/S0040-4020(01)82064-0
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摘要: Relative rates kax and keq of addition reactions to title compounds have been measured in eight different reaction conditions. The effect changing the axial substituent position 3 4 carbonyl group from -H -Me -CO2R is described. Data show that stereochemical product ratios kaxkeq changes originate sometimes uneven increase (or decrease) both their divergent change. This last case points a nucleophylic vs. electrophylic character equatorial attack.
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