Stevens-Johnson syndrome and toxic epidermal necrolysis in Thailand.

摘要: Background. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially life-threatening illnesses that have often been linked to drug exposure. Methods. We looked retrospectively for all cases of SJS TEN were admitted Siriraj Hospital between 1981 1990 determine the etiology. Results. Fifty-eight 20 identified. Eight patients initially had an SJS-like aspect, which subsequently evolved into TEN. A culpable was determined in 60 (77%). The mean time from first administration onset or 6.8 ± 6.5 days (range, 1 28 days). longer incubation period observed with thiacetazone (10.5 5.6 days), phenytoin (12 8.5 carbamazepine (11.3 3.4 days). Conclusions. culprit drugs included following: antibiotics, 32 (penicillin, sulfonamides, tetracycline, erythromycin); anticonvulsants, nine (phenytoin, carbamazepine, barbiturates); antitubercular drugs, eight (thiacetazone); analgesics, four (acetylsalicylic acid, fenbufen); sulfonylurea, two; allopurinol, one; others, four. most frequent underlying diseases justifying ingestion one more our infections (52.7%), followed by pulmonary tuberculosis (10.8%), seizures (8.1%). total mortality rate 14%; 5% SJS, 40% Mortality not affected type responsible.