Drug‐induced Stevens–Johnson syndrome: case series from tertiary care centre in Gujarat

摘要: Purpose The aims of the present article were to study clinical features and analyse them in different drug class associated with Stevens– Johnson syndrome (SJS) a tertiary care hospital Gujarat, India. Materials Methods A prospective hospital-based was carried out over period 3years (June 2007 September 2009) at Sheth Vadilal Hospital, Ahmedabad, diagnosis SJS made mainly on basis findings, which included extensive erythema multiforme, purpuric lesions bullae detachment skin involving least two mucous membranes. Further, each patient suspected SJS, various laboratory tests such as complete blood count, liver function tests, metabolic panel, chest X-ray other serological test out. confirmed most widely accepted Bastuji-Garin definition. Causality assessment performed using Naranjo scale. Only ‘probable’ ‘definite’ reactions included. Results Antibacterialsforsystemic use,anti-inflammatory andantirheumaticproductsandantiepilepticswerethe drugclassesmostcommonly (8 29 cases, each) SJS. Individually, ibuprofen involved highest number cases (five 17.2%), followed by carbamazepine (fourcases,13.8%). ThemeandurationofdevelopingSJSsymptomswas15.9days(SD=8.7days)andimprovementaftertreatmentwas14.2days(SD=4.6days).The durationofappearingSJSsymptomsvariedsignificantlybetweendifferentclassesofdrugs(p<0.001). appearance ofSJS symptom started within 10days foranti-inflammatory antibacterialcompared 24daysofantiepileptic agents. All patients withantiepileptic agent–induced had 7% to9%ofdetached body surface area. Intwo patients, progressed totoxic epidermal necrolysisandofwhichone ledtodeathand theotherdevelopedlong-termcomplicationofconjunctivalxerosis. Atotalofsixpatientsdeveloped long-term complications: four conjunctival synechia, one xerosis urethral stricture. Conclusion More than 80% events induced antibacterial, anti-inflammatory antiepileptic agents same frequency. duration symptoms significantly varied between classes for antibacterial compared 24days Copyright © 2012 John Wiley & Sons, Ltd. key words—Stevens–Johnson syndrome; ibuprofen; antibiotics; India; analgesics; antiepileptics