Interaction study of ciprofloxacin with human telomeric DNA by spectroscopy and molecular docking.
作者： Huihui Li , Xiaoyang Bu , Jia Lu , Chongzheng Xu , Xianlong Wang
DOI: 10.1016/J.SAA.2013.01.069
关键词:
摘要: Abstract The interaction of ciprofloxacin (CIP) with human telomeric DNA was studied in vitro using multi-spectroscopy and molecular modeling methods. hypochromic effect a red shift ultraviolet (UV) absorption indicated the occurrence between CIP DNA. fluorescence quenching observed addition proved to be static quenching. binding constant found 9.62 × 104 L mol−1. Electrospray ionization mass spectrometry (ESI-MS) result further confirmed formation 1:1 non-covalent complex CIP. Combined UV melting results, circular dichroism (CD) results existence groove mode, as well conformational changes Molecular docking studies illustrated visual display GC region minor Specific hydrogen bonds van der Waals forces were demonstrated main acting guanine bases
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