Safety and Clinical Impact of a Single Red Light Irradiation on Breast Tumor-Bearing Mice.
作者： Saulo T. Pereira , Camila R. Silva , Silvia C. Nuñez , Martha S. Ribeiro
DOI: 10.1111/PHP.13338
关键词:
摘要: Low-level light therapy has been used in health care as a therapeutic strategy for different diseases. However, its effects on cancer are controversial. This work evaluated the of three energies breast cancer-bearing mice after single red light-emitting diode (LED) irradiation. 4T1 cells were inoculated into mammary fat pad female BALB/c mice. When tumor volume reached 100 mm3 , animals irradiated by LED irradiator (660 ± 11 nm) with 1.2, 3.6, and 6.0 J. Control without irradiation healthy also evaluated. Mice monitored regarding total blood count. After euthanasia, their organs examined. We observed that does not increase volume. All groups exhibited better clinical conditions than control, which presented significant decrease platelet cell levels compared The energy 3.6 J arrested neutrophil-lymphocyte rate besides promoting longer survival lower number metastatic nodules lungs. These findings suggest causes no impact course disease. Besides, intermediary dose-effect should be further investigated since it seems to promote outcomes
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