Tumor associated macrophages and neutrophils in cancer.

摘要: The tumor microenvironment is a complex framework, in which myeloid cells play important roles sculpting cancer development from initiation to metastasis. Immune are key participants of the where they can promote or inhibit formation and development. Plasticity widely accepted hallmark particular monocyte-macrophage lineage. It includes ability display wide spectrum activation states response distinct signals classical M1 alternative M2 macrophages represent paradigm this feature. Neutrophils have long been viewed as terminally differentiated effector cells, playing major role during acute phase inflammation resistance against microbes. Recent evidence questioned limited point view, indicating that neutrophils interact with cell populations produce number cytokines molecules. Therefore, both integrated regulation innate adaptive immune responses various inflammatory situations, including cancer.