Neutrophils Activate Tumoral CORTACTIN to Enhance Progression of Orohypopharynx Carcinoma

摘要: CORTACTIN is an actin-binding protein critically involved in cellular migration and invasion. Here, we investigated the role of pathophysiology orohypopharynx carcinoma – one major subtypes head neck cancer. To this end, analysed expression tumor tissues from 89 patients relation to clinical parameters. We found that high tumoral associated with poor survival, higher T-stage lymph node metastasis (N-stage) these patients. Next, combined prognostic values stromal cell biological parameters our patient cohort. determined potential interaction tumor-infiltrating neutrophils, which have been previously linked outcome advanced disease. Interestingly, both neutrophilic infiltration had significantly worse than all other These findings suggest neutrophils might be functionally during progression carcinoma. In vitro, showed released soluble factors phosphorylated cells promoted their migration. Furthermore, demonstrated strong phosphorylation correlated Taken together, unravel a novel mechanism tumor-stroma interaction, relevant for more accurate prognosis improved therapeutic strategies entity.