Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol.

摘要: This study investigated the effect of gossypol on hyperplastic canine prostates induced with long-term administration androgen and estrogen. Twelve 16-week-old male beagle dogs were divided evenly (n = 3) into 4 treatment groups: (1) CONTROL: vehicle only; (2) Gossypol-Treated: 20 mg/kg acetic acid; (3) Steroid-Induced: testosterone 40 micrograms/kg estradiol-17 beta; (4) Gossypol-Treated testosterone, beta gossypol. The subjects received treatments every other day for 1 month. beagles treated steroids developed an acute enlargement (approximately 10-fold) prostate as compared to control. prostatic acini underdeveloped characterized by simple squamous low cuboidal epithelium in control while steroid-induced tall columnar epithelium. had histologically similar controls exception loosened periurethral connective tissue. Serum levels imply that can reduce steroid hormonal levels. Mean serum gossypol-treated reduced approximately 50% from controls. biochemistry profiles indicate and/or not toxic at doses duration used this study. These observations hormones interact alter development metabolism clearance.