Stromal and epithelial cells of the canine prostate express parathyroid hormone-related protein, but not the PTH/PTHrP receptor.
作者： Eric A.G. Blomme , Yasuro Sugimoto , Laurie K. McCauley , Young C. Lin , Charles C. Capen
DOI: 10.1002/(SICI)1097-0045(19980701)36:2<110::AID-PROS6>3.0.CO;2-M
关键词:
摘要: BACKGROUND Parathyroid hormone-related protein (PTHrP), a principal factor in the pathogenesis of humoral hypercalcemia malignancy, is also widely expressed many normal tissues, including human prostatic epithelial cells. The role PTHrP prostate not known, but may include regulation cell growth and differentiation or calcium secretion into fluid. dog valuable animal model for diseases. objective was to investigate expression PTH/PTHrP (type 1) receptor primary cultures canine stromal cells. METHODS Expression measured homogenous cells using immunohistochemistry, Northern blots, radioimmunoassay, RT-PCR, stimulation assays. RESULTS Epithelial secreted abundant PTHrP, detected either type. CONCLUSIONS PTHrP by absence I) suggest that some functions previously proposed are unlikely. separation procedure presented tool studying prostate. Prostate 36:110–120, 1998. © 1998 Wiley-Liss, Inc.
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