Lysosomal proteins produced in the milk of transgenic animals
作者： Martin Ph. Verbeet , Ans T. Van der Ploeg , Frank R. Pieper , Arnold J. J. Reuser
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摘要: The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at 6' position a mannose side chain residue. Also provided are purifying from incorporating into pharmaceutical compositions for use enzyme replacement therapy.
lens.org 参考文章(16)
Van Hoof F, de Barsy T, Jacquemin P, Hers Hg, Enzyme replacement in Pompe disease: an attempt with purified human acid alpha-glucosidase. Birth defects original article series. ,vol. 9, pp. 184- ,(1973)
Noshi MINAMIURA, Koji MATOBA, Hiroshi NISHINAKA, Takehiko YAMAMOTO, Identity of .ALPHA.-glucosidase of human kidney with urine F-1 .ALPHA.-glucosidase. Journal of Biochemistry. ,vol. 91, pp. 809- 816 ,(1982) , 10.1093/OXFORDJOURNALS.JBCHEM.A133768
Agnes G.A. Bijvoet, Marian A. Kroos, Frank R. Pieper, Herman A. de Boer, Arnold J.J. Reuser, Ans T. van der Ploeg, Martin Ph. Verbeet, Expression of cDNA-encoded human acid α-glucosidase in milk of transgenic mice Biochimica et Biophysica Acta. ,vol. 1308, pp. 93- 96 ,(1996) , 10.1016/0167-4781(96)00093-0
Linda V. Oberkotter, Otakar Koldovsky, Alfred Tenore, N-acetyl-β-hexosaminidase activity in human breast milk☆ International Journal of Biochemistry. ,vol. 14, pp. 151- 154 ,(1982) , 10.1016/0020-711X(82)90155-0
Henri Rochefort, Françoise Capony, Patrick Augereau, Vincent Cavailles, Marcel Garcia, Muriel Morisset, Gilles Freiss, Thierry Maudelonde, Françoise Vignon, The estrogen-regulated 52K-cathepsin-D in breast cancer: from biology to clinical applications. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. ,vol. 14, pp. 377- 384 ,(1987) , 10.1016/0883-2897(87)90015-8
Louis-Marie Houdebine, Production of pharmaceutical proteins from transgenic animals Journal of Biotechnology. ,vol. 34, pp. 269- 287 ,(1994) , 10.1016/0168-1656(94)90062-0
Gerard J. Platenburg, Erika P. A. Kootwijk, Patricia M. Kooiman, Shelley L. Woloshuk, Jan H. Nuijens, Paul J. A. Krimpenfort, Frank R. Pieper, Herman A. de Boer, Rein Strijker, Expression of human lactoferrin in milk of transgenic mice. Transgenic Research. ,vol. 3, pp. 99- 108 ,(1994) , 10.1007/BF01974087
Alison K. Barnes, Colin H. Wynn, Homology of lysosomal enzymes and related proteins: Prediction of posttranslational modification sites including phosphorylation of mannose and potential epitopic and substrate binding sites in the α‐ and β‐subunits of hexosaminidases, α‐glucosidase, and rabbit and human isomaltase Proteins. ,vol. 4, pp. 182- 189 ,(1988) , 10.1002/PROT.340040305
L H Hoefsloot, R Willemsen, M A Kroos, M Hoogeveen-Westerveld, M M Hermans, A T Van der Ploeg, B A Oostra, A J Reuser, Expression and routeing of human lysosomal alpha-glucosidase in transiently transfected mammalian cells. Biochemical Journal. ,vol. 272, pp. 485- 492 ,(1990) , 10.1042/BJ2720485
Herbert L. Heyneker, Rein Strijker, Paul J. A. Krimpenfort, Gerard Platenburg, Frank Pieper, Sang He Lee, Herman A. DeBoer, Production of recombinant polypeptides by bovine species and transgenic methods ,(1990)