Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris

摘要: The effects of coenzyme Q10(CoQ10) on exercise performance were studied in 12 patients, average age 56 years, with stable angina pectoris. study involved a double-blind, placebo-controlled, randomized, crossover protocol, using multistage treadmill tests. CoQ10(150 mg/day 3 daily doses) was administered orally for 4 weeks, tended to reduce anginal frequency from 5.3 +/- 4.9 2.5 3.3 attacks 2 weeks and nitroglycerin consumption 2.6 2.8 1.3 1.7 tablets compared patients receiving the placebo, but reduction not statistically significant. Exercise time increased 345 102 seconds placebo 406 114 during CoQ10 treatment (p less than 0.05). until 1 mm ST-segment depression occurred 196 76 284 104 0.01). During test, depression, heart rate pressure-rate product at same maximal workload showed no significant difference between after administration. plasma concentration 0.95 0.48 microgram/ml 2.20 0.98 treatment. This increase significantly related duration (r = 0.68, p 0.001). Only patient had loss appetite, continued therapy. suggests that is safe promising