The three-tier approach to mt1tagenicity screening and the concept of radiation-equivalent dose

摘要: Summary A three-tier approach to mutagenicity screening is proposed, based on 3 general principles. The first tier consists of in vitro tests which would be the only compounds not intended for direct ingestion subjected, example industrial chemicals. Substances ( e.g. food additives and medicines) together with other widespread substances that might expected accumulate within body would, if they give negative results tests, subjected a second vivo using whole mammals. giving positive either these pass third evaluation. Here object carry out experiments designed quantitative indication potential risk man followed by risk-benefit assessment. It suggested one way comparing effect agent another express it as radiation-equivalent dose (in radeguiv units).