Comparison of changes in lung function measured by plethymography and IOS after bronchoprovocation

摘要: Summary Aim Lung function tests are essential for the diagnosis and management of bronchial asthma. Impulse oscillation (IOS) system is an alternative way to measure lung mechanics some patients. We investigated relative sensitivities IOS, body plethysmography spirometry in detecting allergen- methacholine-induced bronchoconstriction. Method Twenty-two subjects had single allergen inhalation 8 3 methacholine challenges. The were stopped when FEV 1 fell by 20%. was measured using IOS (R5, R20, R5-R20, X5, AX, fres), (sRaw, sGaw, FRC, volumes) (FEV , FVC, PEF, FEF 50% ) during challenges, expressed as percent change from pre-challenge baseline. Results All non-smoking adults with mild allergic Following most sensitive index R5–R20 measurements sRaw, sGaw . challenge measurement sRaw. Overall, (R5–R20, X5Hz) proved be more than following allergen-induced Conclusion Our result shows that other challenge. In addition, can act technique airway resistance obstruction patients where manoeuvres involved prove difficult perform.