Association between EGF +61 A>G polymorphism and gastric cancer risk: A meta-analysis.
作者： Song-jie Wu , Si-yu Jiang , Jing Wu , Guang-lian Xiong
DOI: 10.1007/S11596-015-1432-3
关键词:
摘要: Previous studies suggested an association between the EGF +61 A>G polymorphism and susceptibility to gastric cancer, but results have been inconsistent. To draw a more precise risk estimation of association, we performed meta-analysis published studies. PubMed, EMBASE, Google Scholar Chinese Wanfang databases were systematically searched identify relevant There 7 involving 1992 cases cancer 3202 controls in this meta-analysis. Our study showed that, overall, was significantly associated with increased allele model (G vs. A: OR=1.18, 95% CI=1.00–1.39), dominant (GG + GA AA: OR=1.28, CI=1.05–1.55), homozygous OR=1.31, CI=1.06–1.63) heterozygous (GA OR=1.25, CI=1.01–1.53). The stratified analysis by ethnicity revealed significant risks Asians. This indicates that may increase especially Large-sized, well-designed different ethnic groups should be conducted confirm association.
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sci-hub.se 参考文章(41)
Lanfranco D’Elia, Ferruccio Galletti, Pasquale Strazzullo, Dietary Salt Intake and Risk of Gastric Cancer Cancer treatment and research. ,vol. 159, pp. 83- 95 ,(2014) , 10.1007/978-3-642-38007-5_6
G Carpenter, S Cohen, Epidermal growth factor. Journal of Biological Chemistry. ,vol. 265, pp. 7709- 7712 ,(1972) , 10.1016/S0021-9258(19)38983-5
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. ,vol. 136, ,(2015) , 10.1002/IJC.29210
Ying Piao, Zhaozhe Liu, Zhenyu Ding, Long Xu, Fang Guo, Qingqing Sun, Xiaodong Xie, EGF +61A>G polymorphism and gastrointestinal cancer risk: A HuGE review and meta-analysis Gene. ,vol. 519, pp. 26- 33 ,(2013) , 10.1016/J.GENE.2013.01.057
Takeshi Okuda, Masahiko Onda, Akira Tokunaga, Yuichi Sugisaki, Stimulatory effect of EGF and inhibitory effect of sialoadenectomy on growth of an EGF receptor-hyperproducing human gastric cancer xenograft in nude mice. Surgery Today. ,vol. 24, pp. 725- 733 ,(1994) , 10.1007/BF01636779
Teng-Fei Li, Ke-Wei Ren, Peng-Fei Liu, Meta-Analysis of Epidermal Growth Factor Polymorphisms and Cancer Risk: Involving 9,779 Cases and 15,932 Controls DNA and Cell Biology. ,vol. 31, pp. 568- 574 ,(2012) , 10.1089/DNA.2011.1394
Eric J Duell, Noémie Travier, Leila Lujan-Barroso, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Sophie Morois, Domenico Palli, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, J Ramón Quirós, Emilio Sánchez-Cantalejo, Carmen Navarro, Aurelio Barricarte Gurrea, Miren Dorronsoro, Kay-Tee Khaw, Naomi E Allen, Timothy J Key, H Bas Bueno-de-Mesquita, Martine M Ros, Mattijs E Numans, Petra HM Peeters, Antonia Trichopoulou, Androniki Naska, Vardis Dilis, Birgit Teucher, Rudolf Kaaks, Heiner Boeing, Madlen Schütze, Sara Regner, Björn Lindkvist, Ingegerd Johansson, Göran Hallmans, Kim Overvad, Rikke Egeberg, Anne Tjønneland, Eiliv Lund, Elisabete Weiderpass, Tonje Braaten, Isabelle Romieu, Pietro Ferrari, Mazda Jenab, Roger Stenling, Dagfinn Aune, Teresa Norat, Elio Riboli, Carlos A González, Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort The American Journal of Clinical Nutrition. ,vol. 94, pp. 1266- 1275 ,(2011) , 10.3945/AJCN.111.012351
Guifang Yang, Lan Rao, Li Tian, Xiaojun Cai, An association between EGF and EGFR gene polymorphisms with gastric cancer in a Chinese Han population. Hepato-gastroenterology. ,vol. 59, pp. 2668- ,(2012) , 10.5754/HGE12152
Hongcheng Zhu, Xi Yang, Chi Zhang, Chen Zhu, Guangzhou Tao, Lianjun Zhao, Shaowen Tang, Zheng Shu, Jing Cai, Shengbin Dai, Qin Qin, Liping Xu, Hongyan Cheng, Xinchen Sun, Red and Processed Meat Intake Is Associated with Higher Gastric Cancer Risk: A Meta-Analysis of Epidemiological Observational Studies PLoS ONE. ,vol. 8, pp. e70955- ,(2013) , 10.1371/JOURNAL.PONE.0070955
Y. Goto, No Association Between EGF Gene Polymorphism and Gastric Cancer Cancer Epidemiology, Biomarkers & Prevention. ,vol. 14, pp. 2454- 2456 ,(2005) , 10.1158/1055-9965.EPI-05-0401