Cell aggregation increases drug resistance of acute myeloid leukemia cells
作者： R. S. Fadeev , M. E. Solovieva , D. A. Slyadovskiy , S. G. Zakharov , I. S. Fadeeva
DOI: 10.1134/S1990747815020063
关键词:
摘要: One of the major causes low efficiency therapy for acute myeloid leukemia is drug resistance leukemic cells. Microenvironment plays a key role in formation phenotype cell resistance. Investigation mechanisms microenvironment-mediated important to identify novel pharmacological targets therapy. We studied aggregation showed increased cells THP-1 bortezomib, doxorubicin and fludarabine multicellular aggregates. In aggregates with higher resistance, proliferation activity did not change, while intracellular level anti-apoptotic protein Bcl-2 increased. Inhibition prevented This work demonstrates involvement
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