Cell cycle control in acute myeloid leukemia

摘要: Acute myeloid leukemia (AML) is the result of a multistep transforming process hematopoietic precursor cells (HPCs) which enables them to proceed through limitless numbers cell cycles and become resistant death. Increased proliferation renders these vulnerable acquiring mutations may favor leukemic transformation. Here, we review how deregulated cycle control contributes increased in AML favors genomic instability, prerequisite confer selective advantages particular clones order adapt independently proliferate presence changing microenvironment. We discuss connection between differentiation with regard leukemogenesis outline impact specific alterations on response therapy. Finally, present examples, better understanding regulation deregulation has already led new promising therapeutic strategies.