Significance of troponin elevation after severe traumatic brain injury.

摘要: Introduction: Elevation of serum troponin (cTnI) after nontraumatic cerebral insult has been associated with an adverse prognosis. This association not well documented in traumatic brain injury (TBI). Objective: To evaluate the and prognostic significance cTnI elevation severe TBI. role beta-blocker (BB) therapy TBI patients elevated cTnI. Methods: Retrospective review all blunt trauma (head Abbreviated Injury Scale score [AIS] >3) admitted to intensive care unit (ICU) serial TnI measurements at a Level I center from January 1998 December 2005. Patients AIS >3 other body regions were excluded. Univariate multivariate logistic regression was performed determine elevation. Results: There 420 who had during study period. One hundred twenty-five (29.8%) admission lower Glasgow Coma (GCS) (7.5 vs. 8.7, p < 0.05), higher Severity Score (27.4 24.8, 0.01), increased hospital mortality (44% 29%, compared normal Increasing severity head increasing (TnI level 0.8 g/L for 3 0.3 4, 5, 0.09). After adjusting severity, independent predictor (Odds ratio [OR[: 8.5; 95% confidence interval [CI]: 3.46, 22.15, 0.0001). BB significant survival advantage (OR: 0.38; CI: 0.15, 0.87, 0.03) any Conclusion: Elevated is frequently observed The correlates outcomes.