RECOMBINANT HUMAN INTERLEUKIN-6 INDUCES A RAPID AND REVERSIBLE ANEMIA IN CANCER-PATIENTS
作者： J Nieken , NH Mulder , J Buter , E Vellenga , PC Limburg
DOI: 10.1182/BLOOD.V86.3.900.900
关键词:
摘要: Initial studies have shown that recombinant human interleukin-6 (rhIL- 6) induces anemia. Until now, the pathophysiologic mechanism of this induced anemia has been unknown. To unravel underlying mechanism, we examined 15 cancer patients receiving rhIL-6 as an antitumor immunotherapy in a phase II study. was administered subcutaneously at 150 micrograms once daily for 6 consecutive weeks. Various hematologic and biochemical parameters were measured weekly during treatment 4 weeks after discontinuation. determine plasma volume red blood cell (RBC) volume, radioisotope dilution assays with labeled autologous RBCs serum albumin performed before administration on day 8 therapy. Hemoglobin levels decreased (mean change +/- SE) 7% 1.5% within 3 days start therapy (P
narcis.nl参考文章(37)
T Imai, K Koike, T Kubo, T Kikuchi, Y Amano, M Takagi, N Okumura, T Nakahata, Interleukin-6 supports human megakaryocytic proliferation and differentiation in vitro. Blood. ,vol. 78, pp. 1969- 1974 ,(1991) , 10.1182/BLOOD.V78.8.1969.1969
XG Zhang, B Klein, R Bataille, Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma Blood. ,vol. 74, pp. 11- 13 ,(1989) , 10.1182/BLOOD.V74.1.11.11
C Yee, A Biondi, XH Wang, NN Iscove, J de Sousa, LA Aarden, GG Wong, SC Clark, HA Messner, MD Minden, A possible autocrine role for interleukin-6 in two lymphoma cell lines. Blood. ,vol. 74, pp. 798- 804 ,(1989) , 10.1182/BLOOD.V74.2.798.798
T Givon, S Slavin, N Haran-Ghera, R Michalevicz, M Revel, Antitumor effects of human recombinant interleukin-6 on acute myeloid leukemia in mice and in cell cultures Blood. ,vol. 79, pp. 2392- 2398 ,(1992) , 10.1182/BLOOD.V79.9.2392.2392
Shigetaka Asano, Akira Okano, Keiya Ozawa, Tatsutoshi Nakahata, Toshiyuki Ishibashi, Kenichi Koike, Hideo Kimura, Yoshikuni Tanioka, Akira Shibuya, Toshio Hirano, Tadamitsu Kishimoto, Fumimaro Takaku, Yukio Akiyama, In vivo effects of recombinant human interleukin-6 in primates: stimulated production of platelets. Blood. ,vol. 75, pp. 1602- 1605 ,(1990) , 10.1182/BLOOD.V75.8.1602.1602
WC Faquin, TJ Schneider, MA Goldberg, EFFECT OF INFLAMMATORY CYTOKINES ON HYPOXIA-INDUCED ERYTHROPOIETIN PRODUCTION Blood. ,vol. 79, pp. 1987- 1994 ,(1992) , 10.1182/BLOOD.V79.8.1987.1987
A. Zilberstein, R. Ruggieri, J.H. Korn, M. Revel, Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines. The EMBO Journal. ,vol. 5, pp. 2529- 2537 ,(1986) , 10.1002/J.1460-2075.1986.TB04531.X
M Okada, M Kitahara, S Kishimoto, T Kishimoto, T Hirano, T Matsuda, IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells. Journal of Immunology. ,vol. 141, pp. 1543- 1549 ,(1988)
Junming Le, Jan Vilček, Interleukin 6: a multifunctional cytokine regulating immune reactions and the acute phase protein response. Laboratory Investigation. ,vol. 61, pp. 588- 602 ,(1990) , 10.1007/978-1-4612-0485-5_7
Anne Vink, Catherine Uyttenhove, Pierre Wauters, Jacques van Snick, Accessory factors involved in murine T cell activation. Distinct roles of interleukin 6, interleukin 1 and tumor necrosis factor. European Journal of Immunology. ,vol. 20, pp. 1- 6 ,(1990) , 10.1002/EJI.1830200102