Metabolic and physiologic effects of rhEPO in anemic cancer patients

摘要: Anemia in cancer disease is usually regarded a consequence of progression explained by several factors, but may as well be contributing factor and promoter behind the wasting patients (Mittelman 1996; Moliterno Spivak Bertero Caligaris-Cappio 1997). This unusual concept goes back to our previous studies, which have revealed both increased adrenergic activity sensitivity (Drott et al. 1989), phenomenon probably related cardiovascular system indicated either elevated resting heart rate excretion stress hormones with progressive weight loss, including altered cardiac adrenoceptor expression tissue from tumor bearing animals 1987; Drott 1988; Hyltander 1991). Results laboratory have, thus, suggested anemia energy expenditure patients, although also host systemic inflammation (Fig. 1). However, it has never been evaluated whether anti-inflammatory treatment itself, reducing cytokine production, would sufficient prevent or attenuate any significant extent (Nieken 1995). Our recent data suggest that can weight-losing (Lundholm 2004b), agreement findings provision fish oils pancreatic carcinoma leading improved status (Barber 1999). Open image new window Fig. 1. Relationship between blood hemoglobin concentration unselected (r = 0.42, p < 0.001)