The Ganglionic Eminence May Be an Intermediate Target for Corticofugal and Thalamocortical Axons

摘要: In the nervous system of many species, growing axons associate transiently with cellular groupings along their path. Whether this mechanism applies to development corticothalamic and thalamocortical projections is unknown. Using carbocyanine dyes, we studied early growth both corticofugal fibers in hamster embryos. At embryonic day 11.5 (E11.5), invade lateral ganglionic eminence (LGE), medial (MGE). age, sets are not yet contact each other. same time, neurons subdivision GE grow toward cortex thalamus. During next 24 hr, remain within confines GE, where they course at different radial levels bear large complex cones. LGE, often found close association cells that likely be neuronal. Starting on E13.5, from decrease, definitive target regions. To test whether specifically orients trajectories cortical even absence reciprocal thalamic projection, cocultured explants either or mouse These experiments showed but other tested brain regions, able orient axons. We therefore suggest may an intermediate pathfinding between