Updated meta-analysis of the association between CYP2E1 RsaI/PstI polymorphisms and lung cancer risk in Chinese population.

摘要: Background: A number of studies have reported relationships CYP2E1 RsaI/PstI polymorphisms with susceptibility to lung cancer in Chinese population. However, the epidemiologic results been conflictive rather than conclusive. The purpose this study was address associations risk population comprehensively. Materials and Methods: Systematic searches were conducted PubMed, Science Direct, Elsevier, CNKI Biomedical Literature Databases. Pooled odds ratios (ORs) 95% confidence intervals (CIs) calculated estimate strength association. Results: Overall, we observed a decreased among subjects carrying c1/ c2 c1/c2+c2/c2 genotypes (OR=0.76, 95%CI: 0.64-0.90 OR=0.78, 0.66-0.93, respectively), as compared c1/c1 genotype. In subgroup analysis, c1/c2 carriers hospital-based (OR=0.81, 0.68-0.98) population-based studies(OR=0.57, 0.42-0.79 OR=0.58, 0.43-0.79, Limiting analysis controls Hardy-Weinberg equilibrium (HWE), similarly (OR=0.73, 0.60-0.88 OR=0.73, 0.60-0.88, c1/c1. Conclusions: Our suggested that variants might be protective factor for developing Further well-designed larger sample size are required verify our findings.