Role of household exposure, dietary habits and glutathione S-Transferases M1, T1 polymorphisms in susceptibility to lung cancer among women in Mizoram India.

摘要: Background: A case-control study was conducted to evaluate the effect of household exposure, dietary habits, smoking and Glutathione S-Transferases M1, T1 polymorphisms on lung cancer among women in Mizoram, India. Materials Methods: We selected 230 newly diagnosed primary cases 460 controls from Mizoram. Multivariate logistic regression analysis performed estimate adjusted odds ratio (OR). Results: Exposure cooking oil fumes (p<0.003), wood as heating source for (p=0.004), kitchen inside living room (p=0.001), improper ventilated house (p=0.003), roasting soda current smokers tobacco (p=0.043), intake smoked fish (p=0.006), meat Soda (p<0.001) GSTM1 null genotype (p=0.003) were significantly associated with increased risk Significantly protective observed bamboo shoots (p=<0.001) egg (p<0.001). clear increase dose response gradient total dish years. Risk tends collegial indoor environmental sources (p=0.022). Significant correlation also interaction GST some habits. Conclusions: confirmed important role exposure emission smoke, meat, (an alkali preparation used food additives Mizoram) consumption Women