A Repeated Amphetamine Model of Impaired Attention in Schizophrenia.

摘要: Cognitive impairments, including deficits in attention processing, represent major and central elements of schizophrenic symptoms. Firstand secondgeneration antipsychotic drugs can effectively mitigate the florid symptoms psychosis. However, treating schizophrenia’s cognitive remains problematic has met with limited success. Evidence indicates that basal forebrain cholinergic system (BFCS) is an essential component neuronal circuitry involved mediating processing processingan important aspect cognition. The present thesis based on core hypothesis dysregulation contributes to impairments associated Using a repeated-amphetamine (AMPH) rat model schizophrenia, following main hypotheses are tested: 1) Repeated, escalating AMPH administration, followed by ‘AMPHchallenges’ at previously innocuous doses, results performance task measures sustained attention. 2) consequences repeated-AMPH administration subsequent challenge dosing task-performing animals include dysregulated cortical transmission. 3) In AMPH-pretreated performing task; sub-chronic, low-dose will attenuate impairments. findings provide evidence for aberrant regulation impaired schizophrenia. Specifically, pretreatment resulted markedly attenuated