Behavioral changes and [123I]IBZM equilibrium SPECT measurement of amphetamine-induced dopamine release in rhesus monkeys exposed to subchronic amphetamine.

摘要: Previously we have shown that twelve weeks of repeated low-dose d-amphetamine (AMPH) exposure in rhesus monkeys induces a long-lasting enhancement behavioral responses to acute challenge. The present study was designed investigate the and neurochemical consequences six-week regimen AMPH (0.1–1.0 mg/kg, i.m., b.i.d.) monkeys. SPECT imaging AMPH's (0.4 mg/kg) ability displace [123I]IBZM bound D2 dopamine receptors striatum saline control AMPH-treated animals prior following chronic treatment accomplished using bolus/constant infusion paradigm. Following treatment, all showed an enhanced response challenge significant decrease percent AMPH-induced displacement compared their pretreatment scans. These findings suggest relatively small changes presynaptic function may be reflected alterations