Prevalence, incidence, and type-specific persistence of human papillomavirus in human immunodeficiency virus (HIV)-positive and HIV-negative women.

摘要: Human immunodeficiency virus (HIV) infection and related immunosuppression are associated with excess risk for cervical neoplasia human papillomavirus (HPV) persistence. Type-specific HPV was assessed at 6-month intervals HIV-positive HIV-negative women (median follow-up, 2.5 2.9 years, respectively). The type-specific incidence of determined, factors persistence were investigated by statistical methods that accounted repeated measurements. 1.8, 2.1, 2.7 times more likely to have high-, intermediate-, low-risk infections, respectively, compared women. In multivariate analysis, high viral signal, but not category, independently among subjects (odds ratio [OR], 2.5; 95% confidence interval [CI], 2.1-2.9). Furthermore, 1.9 (95% CI, 1.5-2.3) greater if the subject had a CD4 cell count 500 cells/microL). Thus, HIV play an important role in modulating natural history infection.