Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer.
作者： Keng-Ling Wallin , Fredrik Wiklund , Tord Ångström , Frank Bergman , Ulf Stendahl
DOI: 10.1056/NEJM199911253412201
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摘要: Background Infection with the human papillomavirus (HPV) has been established as a cause of cervical cancer, but the association between a positive test for HPV DNA and the risk of the subsequent development of invasive cervical cancer is unknown. Methods In a study of women who participated in a population-based screening program for cancer of the cervix in Sweden from 1969 to 1995, we compared the proportion of normal cervical smears (Pap smears) that were positive for HPV DNA among 118 women in whom invasive cervical …
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