摘要: … PDKl and AKT. The phosphatase and tensin homolog (PTEN) gene encodes a phosphatase that opposes the action of PI3K, thereby reducing the level of activated AKT. AKT controls …
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Nathalie M. Mazure, Eunice Y. Chen, Keith R. Laderoute, Amato J. Giaccia, Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element Blood. ,vol. 90, pp. 3322- 3331 ,(1997) , 10.1182/BLOOD.V90.9.3322
Alex Toker, Lewis C. Cantley, Signalling through the lipid products of phosphoinositide-3-OH kinase Nature. ,vol. 387, pp. 673- 676 ,(1997) , 10.1038/42648
Peter J. Ratcliffe, Christopher W. Pugh, Patrick H. Maxwell, Targeting tumors through the HIF system. Nature Medicine. ,vol. 6, pp. 1315- 1316 ,(2000) , 10.1038/82113
Pablo Rodriguez-Viciana, Patricia H. Warne, Ritu Dhand, Bart Vanhaesebroeck, Ivan Gout, Michael J. Fry, Michael D. Waterfield, Julian Downward, PHOSPHATIDYLINOSITOL-3-OH KINASE AS A DIRECT TARGET OF RAS Nature. ,vol. 370, pp. 527- 532 ,(1994) , 10.1038/370527A0
Stefanie Dimmeler, Ingrid Fleming, Beate Fisslthaler, Corinna Hermann, Rudi Busse, Andreas M. Zeiher, Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Nature. ,vol. 399, pp. 601- 605 ,(1999) , 10.1038/21224
David Fulton, Jean-Philippe Gratton, Timothy J. McCabe, Jason Fontana, Yasushi Fujio, Kenneth Walsh, Thomas F. Franke, Andreas Papapetropoulos, William C. Sessa, Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. ,vol. 399, pp. 597- 601 ,(1999) , 10.1038/21218
Brian Fendly, Mien Chie Hung, Robert S. Kerbel, Alicia M. Viloria Petit, Patricia Rockwell, Neil Goldstein, Janusz Rak, Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. American Journal of Pathology. ,vol. 151, pp. 1523- 1530 ,(1997)
Zhenping Zhu, Meilin Liu, Human anti-epidermal growth factor receptor antibody ,(2005)
Paul Perrotte, Hiroki Kuniyasu, Beryl Y. Eve, Daniel J. Hicklin, Keiji Inoue, Colin P. N. Dinney, Robert Radinsky, Takashi Matsumoto, Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clinical Cancer Research. ,vol. 5, pp. 257- 265 ,(1999)
Friedrich Kallinowski, Paul Okunieff, Peter Vaupel, Blood Flow, Oxygen and Nutrient Supply, and Metabolic Microenvironment of Human Tumors: A Review Cancer Research. ,vol. 49, pp. 6449- 6465 ,(1989)