Phosphorylation of CaMKII in the rat dorsal raphe nucleus plays an important role in sleep-wake regulation
作者： Su-Ying Cui , Sheng-Jie Li , Xiang-Yu Cui , Xue-Qiong Zhang , Bin Yu
DOI: 10.1111/JNC.13431
关键词:
摘要: The Ca(2+) modulation in the dorsal raphe nucleus (DRN) plays an important role sleep-wake regulation. Calmodulin-dependent kinase II (CaMKII) is signal-transducing molecule that activated by . This study investigated effects of intracellular /CaMKII signaling DRN on states rats. Maximum and minimum CaMKII phosphorylation was detected at Zeitgeber time 21 (ZT 21; wakefulness state) ZT 3 (sleep state), respectively, across light-dark rhythm Six-hour sleep deprivation significantly reduced DRN. Microinjection CAMKII activation inhibitor KN-93 (5 or 10 nmol) into suppressed enhanced rapid-eye-movement (REMS) non-REM (NREMS). Application a high dose (10 increased slow-wave (SWS) time, SWS bouts, mean duration SWS, percentage relative to total sleep, delta power density during NREMS. CaCl2 (50 decreased NREMS, REMS. abolished inhibitory These data indicate novel wake-promoting sleep-suppressing for pathway neurons. We propose Intra-DRN application (CaMKII inhibitor) non-REMS attenuated REMS think these findings should provide cellular molecular mechanism
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