The detection and management of early HIV infection: A clinical and public health emergency

摘要: This review considers the detection and management of early HIV infection (EHI), defined here as first 6 months infection. phase is clinically important because a reservoir infected cells formed in individual renders incurable, magnitude viremia at end this period predicts natural history disease. Epidemiologically, it critical very high viral load that typically accompanies also makes individuals maximally contagious to their sexual partners. Future efforts prevent transmission with expanded testing treatment may be compromised by elevated risk earlier course infection, although extent impact yet unknown. Treatment prevention will nevertheless need develop strategies address testing, linkage care, EHI. Cost-effective efficient identification more persons depend on advancements diagnostic technology strengthened symptom-based screening strategies. for EHI must balance health benefits reduction onward transmission. An increasing body evidence supports use immediate antiretroviral therapy treat maintain CD4 count functionality, limit size reservoir, reduce Although we can anticipate considerable challenges identifying linking care earliest phases there are many reasons pursue strategy.