Role of microRNA‑150‑5p/SRCIN1 axis in the progression of breast cancer
作者： Qingfu Lu , Zhaoji Guo , Haixin Qian
关键词:
摘要: In China, breast cancer is the most commonly occurring in women. MicroRNAs (miRs) are a group of endogenous small non-coding RNAs, which serve role many biological processes through regulation target genes. current study, miR-150-5p expression was significantly up-regulated tissues and cell lines. To investigate cellular function underlying molecular mechanism cancer, TargetScan7.2 used to identify SRC kinase signaling inhibitor 1 (SRCIN1) identified as direct gene study demonstrated that SRCIN1 negatively regulated by cells. Furthermore, down-regulated Taken together, these results there negative association between cancer. The CCK-8 Transwell assays were examine viability, invasion migration ability. over-expression enhanced proliferation, migration. addition, increased mesenchymal markers (vimentin, N-cadherin β-catenin) decreased epithelial (E-cadherin zonula occludens-1). By contrast, knockdown inhibited Additionally, markers. suggest miR-150-5p/SRCIN1 axis may be potential treatment
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